Cetylpyridinium chloride a matsayin Maganin COVID-19

Gwajin ya nuna yawan magungunan kashe ƙwayoyin cuta na quaternary ammonium a matsayin maganin ƙwayoyin cuta da yawa, gami da coronaviruses: waɗannan suna aiki ta hanyar kashe murfin lipid mai kariya wanda ya lulluɓe ƙwayoyin cuta kamar SARS-CoV-2. Ana ba da shawarar mahaɗan ammonium na Quaternary don kashe ƙwayoyin cuta kuma akwai samfura sama da 350 a cikin Jerin N: Magungunan kashe ƙwayoyin cuta na EPA don amfani da su akan SARS-CoV-2 (Karin Kayan aiki. An bayar da rahoton yawan magungunan kashe ƙwayoyin cuta da lokutan hulɗa (wanda ke da alaƙa da ƙwayoyin cuta da yawa) ga yawancin magungunan kashe ƙwayoyin cuta da ke cikin jerin EPA kuma sama da 140 na iya kashe ƙwayar cutar cikin 'yan mintuna kaɗan (18).
Wannan bayanin ya kai mu ga babban bincike don gano mahaɗan ammonium na quaternary waɗanda ke aiki akan coronaviruses da kuma yiwuwar gano sinadarai waɗanda aka riga aka gwada a asibitin kuma ana iya amfani da su azaman maganin COVID-19. Ɗaya daga cikin magungunan kashe ƙwayoyin cuta waɗanda aka nuna suna da illa ga ƙwayoyin cuta (Karin Kayan) kuma ana amfani da su sosai a cikin kayayyakin kulawa na mutum shine cetylpyridinium chloride. Wannan mahaɗin ana samunsa galibi a cikin wanke baki kuma FDA ta lissafa shi a matsayin Mai Tsaro (GRAS) don haka ana amfani da shi azaman maganin kashe ƙwayoyin cuta ga nama da kaji (har zuwa 1%). An yi amfani da Cetylpyridinium chloride a cikin gwaje-gwajen asibiti da yawa, gami da magani akan cututtukan numfashi wanda ke tabbatar da amfaninsa azaman maganin rigakafi. Cetylpyridinium yana iya haɓaka rashin aiki na ƙwayoyin cuta ta hanyar lalata capsid da kuma ta hanyar aikin lysosomotropic, wanda, kamar yadda aka tattauna a sama, ya zama ruwan dare ga mahaɗan ammonium na quaternary. Wannan ya haifar da tambaya game da ko wasu magungunan da aka gano suna da tasirin hana ƙwayoyin cuta ga SARS-CoV-2 a cikin vitro suna yin aiki iri ɗaya, wato suna iya lalata capsid ɗin ƙwayar cuta da kuma taruwa a cikin lysosome ko endosomes sannan daga ƙarshe su toshe shigar ƙwayoyin cuta. Ƙarin binciken da aka buga sun nuna cewa za a iya rage wannan tasirin ta hanyar amfani da masu hana Cathepsin-L.