Cov kev sim tau qhia txog kev siv cov tshuaj tua kab mob quaternary ammonium ntau heev los kho ntau yam kab mob, suav nrog cov kab mob coronaviruses: cov no ua haujlwm los ntawm kev ua kom cov txheej txheem lipid tiv thaiv uas cov kab mob zoo li SARS-CoV-2 vam khom. Cov tshuaj quaternary ammonium tau pom zoo kom tua cov kab mob thiab muaj ntau dua 350 yam khoom ntawm EPA Daim Ntawv Teev Npe N: Cov Tshuaj Tua Kab Mob rau kev siv tawm tsam SARS-CoV-2 (Cov Khoom Siv Ntxiv. Cov tshuaj tua kab mob thiab lub sijhawm sib cuag (cuam tshuam nrog ntau yam kab mob) rau ntau yam tshuaj tua kab mob ntawm daim ntawv teev npe EPA tau tshaj tawm thiab > 140 tuaj yeem ua kom cov kab mob tsis ua haujlwm hauv ob peb feeb xwb (18).
Cov ntaub ntawv no tau coj peb mus nrhiav ntau yam tshuaj quaternary ammonium uas muaj zog tiv thaiv kab mob coronaviruses thiab tej zaum yuav muaj cov tshuaj uas twb tau sim hauv tsev kho mob lawm thiab siv tau los kho COVID-19. Ib qho tshuaj tua kab mob uas tau pom tias ua rau cov kab mob puas tsuaj (Cov Khoom Siv Ntxiv) thiab siv dav hauv cov khoom siv tu cev yog cetylpyridinium chloride. Cov tshuaj no feem ntau pom muaj nyob rau hauv cov tshuaj ntxuav qhov ncauj thiab FDA tau teev tseg tias Muaj Kev Nyab Xeeb (GRAS) uas nws kuj tseem siv tau los ua tshuaj tua kab mob rau cov nqaij thiab cov khoom nqaij qaib (txog li 1%). Cetylpyridinium chloride tau siv rau hauv ntau qhov kev sim tshuaj, suav nrog kev kho mob tiv thaiv kab mob ua pa uas lees paub tias nws siv tau ua tshuaj tua kab mob. Cetylpyridinium tej zaum yuav ua rau cov kab mob tsis ua haujlwm los ntawm kev rhuav tshem cov capsid thiab los ntawm nws cov kev ua lysosomotropic, uas, raws li tau tham saum toj no, yog ib qho uas muaj rau cov tshuaj quaternary ammonium. Qhov no ua rau muaj lus nug txog seb qee cov tshuaj uas txheeb xyuas nrog kev ua haujlwm tiv thaiv kab mob SARS-CoV-2 hauv vitro puas ua haujlwm zoo sib xws, uas yog lawv tuaj yeem rhuav tshem cov kab mob capsid thiab sib sau ua ke hauv lysosome lossis endosomes thiab thaum kawg thaiv kev nkag mus ntawm cov kab mob. Cov kev tshawb fawb ntxiv tau tshaj tawm tias cov nyhuv no tuaj yeem raug txo los ntawm kev siv Cathepsin-L inhibitors.
Cetylpyridinium chloride (CPC)
Cov tshuaj ammonium quaternary uas muaj cov haujlwm coronavirus paub
| Cov tshuaj molecule | Kev ua haujlwm tiv thaiv kab mob | Lub tshuab | FDA tau pom zoo | Siv |
| Ammonium Chloride | Kab mob coronavirus nas, kab mob siab C, | Lysosomotropic | Yog | Ntau yam kev siv suav nrog metabolic acidosis. |
| Cetylpyridinium chloride | Kab mob khaub thuas, kab mob siab B, kab mob poliovirus 1 | Lub hom phiaj capsid thiab yog lysosomotropic | Yog, GRAS | Tshuaj tua kab mob, tshuaj ntxuav qhov ncauj, tshuaj lozenges hnoos, cov khoom siv tu tus kheej, cov neeg ntxuav thiab lwm yam. |
Lub sijhawm tshaj tawm: Plaub Hlis-16-2021