Cetylpyridinium chloride monga mankhwala a COVID-19

Kuyeseraku kunawonetsa kuti mankhwala ophera tizilombo toyambitsa matenda a quaternary ammonium amapezeka pafupipafupi ngati mankhwala a mavairasi ambiri, kuphatikizapo ma coronavirus: awa amagwira ntchito poletsa mafuta oteteza omwe amaphimba mavairasi monga SARS-CoV-2. Mankhwala a quaternary ammonium amalimbikitsidwa kwambiri kuti aphe mavairasi ndipo pali zinthu zoposa 350 pa Mndandanda N: Mankhwala ophera tizilombo toyambitsa matenda a EPA kuti agwiritsidwe ntchito motsutsana ndi SARS-CoV-2 (Zinthu Zowonjezera. Kuchuluka kwa mankhwala ophera tizilombo komanso nthawi yokhudzana ndi mavairasi ambiri) a mankhwala ambiri ophera tizilombo omwe ali pamndandanda wa EPA zanenedwa ndipo > 140 amatha kuletsa kachilomboka mumphindi zochepa chabe (18).
Izi zatipangitsa kufufuza kwambiri mankhwala a quaternary ammonium omwe ali ndi mphamvu yolimbana ndi ma coronavirus komanso kuzindikira mankhwala omwe ayesedwa kale kuchipatala ndipo angagwiritsidwe ntchito ngati mankhwala ochizira COVID-19. Chimodzi mwa mankhwala ophera tizilombo omwe awonetsedwa kuti ndi owononga mavairasi (Supplementary Material) ndipo amagwiritsidwa ntchito kwambiri mu zinthu zosamalira thupi ndi cetylpyridinium chloride. Mankhwalawa amapezeka kwambiri m'malo otsukira pakamwa ndipo alembedwa ndi FDA ngati General Respected as Safe (GRAS) kotero kuti amagwiritsidwanso ntchito ngati mankhwala opha tizilombo toyambitsa matenda pa nyama ndi nkhuku (mpaka 1%). Cetylpyridinium chloride yagwiritsidwa ntchito m'mayesero angapo azachipatala, kuphatikizapo mankhwala ochizira matenda opumira omwe amatsimikizira kugwiritsidwa ntchito kwake ngati mankhwala opha tizilombo. Cetylpyridinium mwina imalimbikitsa kuletsa mavairasi powononga capsid komanso kudzera mu mphamvu yake ya lysosomotropic, yomwe, monga tafotokozera pamwambapa, ndi yofala kwambiri pa mankhwala a quaternary ammonium. Izi zikubweretsa funso loti kodi mankhwala ena omwe amadziwika kuti ali ndi mphamvu yolimbana ndi mavairasi motsutsana ndi SARS-CoV-2 mu vitro amachita chimodzimodzi, kutanthauza kuti akhoza kuwononga kachilombo ka capsid komanso kusonkhana mu lysosome kapena endosomes ndipo pamapeto pake amaletsa kulowa kwa mavairasi. Kafukufuku wina wofalitsidwa wasonyeza kuti zotsatirazi zitha kuchepetsedwa pogwiritsa ntchito zoletsa za Cathepsin-L.