Cetylpyridinium chloride nk'uburyo bwo kuvura COVID-19

Igerageza ryagaragaje ko imiti yica udukoko ya quaternary ammonium ikunze gukoreshwa cyane mu kuvura virusi nyinshi, harimo na coronavirus: iyi miti ikora mu guhagarika urugi rw’ibinure birinda virusi nka SARS-CoV-2. Ibinyabutabire bya quaternary ammonium birasabwa cyane mu kwica virusi kandi hari ibicuruzwa birenga 350 kuri EPA's List N: Imiti yica udukoko ikoreshwa muri SARS-CoV-2 (Ibikoresho by'inyongera. Ingano y’imiti yica udukoko n’igihe ikoreshwa (bifitanye isano na virusi nyinshi) kuri byinshi mu miti yica udukoko ku rutonde rwa EPA byaragaragaye kandi > 140 bishobora guhagarika virusi mu minota mike gusa (18).
Aya makuru yatumye dukora ubushakashatsi bwagutse ku bintu bya ammonium bya quaternary bifite imikorere irwanya coronavirus ndetse no kumenya imiti yamaze gupimwa mu ivuriro kandi ishobora gukoreshwa nk'umuti ushobora kuvura COVID-19. Imwe mu miti yica udukoko yagaragaye ko yangiza virusi (Ibikoresho by'inyongera) kandi ikoreshwa cyane mu bikoresho byo kwiyitaho ni cetylpyridinium chloride. Iyi miti iboneka cyane mu byogesha mu kanwa kandi FDA yashyize ku rutonde rw'ibipimo bya General Reckoned as Safe (GRAS) ku buryo ikoreshwa no mu miti irwanya udukoko ku nyama n'inkoko (kugeza kuri 1%). Cetylpyridinium chloride yakoreshejwe mu magerageza menshi yo kwa muganga, harimo no kuvura indwara z'ubuhumekero zemeza ikoreshwa ryayo nk'umuti urwanya virusi. Cetylpyridinium ishobora gutuma virusi idakora ikarangizwa ikoresheje capsid ndetse no binyuze mu bikorwa byayo bya lysosomotropic, nkuko byavuzwe haruguru, ikunze gukoreshwa ku bintu bya ammonium bya quaternary. Ibi bitera kwibaza niba imwe mu miti yagaragayeho ko irwanya virusi ya SARS-CoV-2 mu buryo bwa vitro ikora kimwe, ni ukuvuga ko ishobora gusenya virusi ya capsid ndetse no kwirundanya muri lysosome cyangwa endosomes bityo igahagarika kwinjira kwa virusi. Ubundi bushakashatsi bwasohotse bwagaragaje ko iyi ngaruka ishobora kugabanuka hakoreshejwe imiti igabanya ubukana bwa Cathepsin-L.