Kuyedza kwakaratidza kuwanda kwemishonga inouraya utachiona ye quaternary ammonium senzira yekurapa mavhairasi akawanda, kusanganisira coronaviruses: izvi zvinoshanda nekudzima lipid coating inodzivirira iyo yakafukidza mavhairasi akaita seSARS-CoV-2. Mishonga ye quaternary ammonium inokurudzirwa zvakanyanya kuuraya mavhairasi uye kune zvigadzirwa zvinopfuura 350 paEPA's List N: Disinfectants yekushandisa kurwisa SARS-CoV-2 (Supplementary Material. Kuwanda kwemishonga inouraya utachiona uye nguva dzekusangana (dzine chekuita nemavhairasi akawanda) emakemikoro akawanda ekuuraya utachiona pane rondedzero yeEPA zvakashumwa uye >140 zvinogona kudzima hutachiona mumaminitsi mashoma chete (18).
Ruzivo urwu rwakatitungamirira pakutsvaga kukuru kwemakemikari e quaternary ammonium ane simba rekurwisa coronavirus uye kugona kuzivikanwa kwemakemikari akatoedzwa mukiriniki uye anogona kushandiswa semushonga weCOVID-19. Imwe yemishonga yekuuraya utachiona yakaratidzwa kuti inoparadza mavhairasi (Supplementary Material) uye inoshandiswa zvakanyanya muzvigadzirwa zvekuchengetedza muviri i cetylpyridinium chloride. Iyi mishonga inowanikwa zvakanyanya muzvimbuzi zvemuromo uye yakanyorwa neFDA seGenerally Recered as Safe (GRAS) zvekuti iri kushandiswawo semushonga wekuuraya utachiona wenyama nehuku (kusvika 1%). Cetylpyridinium chloride yakashandiswa mumiedzo yakawanda yekiriniki, kusanganisira semushonga wekudzivirira hutachiona hwekufema uchisimbisa kushandiswa kwayo semushonga wekudzivirira utachiona. Cetylpyridinium ingangokurudzira kusashanda kwehutachiona nekuparadza capsid pamwe nekushanda kwayo kwe lysosomotropic, iyo, sezvakakurukurwa pamusoro apa, inowanzo shandiswa kune quaternary ammonium compounds. Izvi zvinomutsa mubvunzo wekuti mimwe yemishonga inozivikanwa ine simba rekurwisa SARS-CoV-2 muropa inoshanda zvakafanana here, kureva kuti inogona kuparadza hutachiona hwecapsid pamwe nekuunganidza mu lysosome kana endosomes uye pakupedzisira ichivhara kupinda kwehutachiona. Zvimwe zvidzidzo zvakaburitswa zvakaratidza kuti mhedzisiro iyi inogona kudzikiswa nekushandisa Cathepsin-L inhibitors.
Cetylpyridinium chloride (CPC)
Makomputa eQuaternary ammonium ane chinozivikanwa che coronavirus
| Molekyulu | Kurwisa utachiona | Maitiro | FDA yakagamuchirwa | Mashandisirwo |
| Ammonium Chloride | Coronavirus yemurini, hepatitis C, | Lysosomotropic | Ehe | Mashandisirwo akasiyana-siyana anosanganisira metabolic acidosis. |
| Cetylpyridinium chloride | Furuwenza, hepatitis B, poliovirus 1 | Inotarisa capsid uye i lysosomotropic | Ehe, GRAS | Mishonga inouraya utachiona, mushonga wekuchenesa muromo, mishonga yekukosora, mishonga yekuchenesa, mishonga yekuchenesa nezvimwewo. |
Nguva yekutumira: Kubvumbi-16-2021