Lolu cwaningo lubonise ukuthi kunezindlela eziningi zokubulala amagciwane ze-quaternary ammonium njengendlela yokwelapha amagciwane amaningi, okuhlanganisa nama-coronavirus: lawa asebenza ngokuyekisa uqweqwe lwamafutha oluvikelayo olumboze amagciwane afana ne-SARS-CoV-2. Ama-compound e-quaternary ammonium anconywa kakhulu ukubulala amagciwane futhi kunemikhiqizo engaphezu kuka-350 ku-List N: Disinfectants ye-EPA yokusetshenziswa ngokumelene ne-SARS-CoV-2 (Izinto Ezingeziwe. Ukugxila kwamagciwane kanye nezikhathi zokuthintana (ezihlotshaniswa namagciwane amaningi) kwamakhemikhali amaningi okubulala amagciwane ohlwini lwe-EPA kuye kwabikwa futhi >140 angalivala igciwane ngemizuzu embalwa nje (18).
Lolu lwazi lusiholele ekusesheni okukhulu kwama-compound e-quaternary ammonium asebenza ngokumelene nama-coronavirus kanye nokuhlonza okungenzeka amakhemikhali asevele evivinyiwe emtholampilo futhi angasetshenziswa njengokwelashwa okungenzeka kwe-COVID-19. Enye yezibulala-magciwane eziye zabonakala zibhubhisa amagciwane (Izinto Ezingeziwe) futhi ezisetshenziswa kabanzi emikhiqizweni yokunakekelwa komuntu siqu yi-cetylpyridinium chloride. Le compound itholakala kakhulu ezihlanzweni zomlomo futhi ibhalwe yi-FDA njenge-Generally Regarded as Safe (GRAS) kangangokuthi isetshenziswa futhi njenge-antimicrobial agent yemikhiqizo yenyama neyenkukhu (kufika ku-1%). I-Cetylpyridinium chloride isetshenziswe ezivivinyweni eziningi zemitholampilo, kufaka phakathi ukwelashwa ngokumelene nezifo zokuphefumula okuqinisekisa ukusetshenziswa kwayo njenge-antiviral. I-Cetylpyridinium cishe ikhuthaza ukungasebenzi kwegciwane ngokubhubhisa i-capsid kanye nesenzo sayo se-lysosomotropic, njengoba kuxoxwe ngenhla, esivame kakhulu kuma-compound e-quaternary ammonium. Lokhu kuphakamisa umbuzo wokuthi eminye yemithi ehlonzwe njengomsebenzi wokulwa namagciwane ngokumelene ne-SARS-CoV-2 in vitro iziphatha ngendlela efanayo yini, okungukuthi ingabhubhisa i-capsid yegciwane kanye nokuqongelela ku-lysosome noma kuma-endosome futhi ekugcineni ivimbele ukungena kwegciwane. Izifundo ezengeziwe ezishicilelwe ziphakamise ukuthi lo mphumela ungancishiswa ngokusebenzisa ama-Cathepsin-L inhibitors.
I-Cetylpyridinium chloride (CPC)
I-quaternary ammonium compounds enomsebenzi owaziwayo we-coronavirus
| I-molecule | Umsebenzi wokulwa negciwane | Indlela yokusebenza | Kuvunyiwe yi-FDA | Ukusetshenziswa |
| I-Ammonium Chloride | i-coronavirus ye-murine, i-hepatitis C, | I-Lysosomotropic | Yebo | Ukusetshenziswa okuhlukahlukene okuhlanganisa i-metabolic acidosis. |
| I-Cetylpyridinium chloride | Umkhuhlane, i-hepatitis B, i-poliovirus 1 | Ihlose i-capsid futhi iyi-lysosomotropic | Yebo, i-GRAS | Imithi yokubulala amagciwane, yokugeza umlomo, imithi yokuhlanza ukukhwehlela, imikhiqizo yokunakekela umuntu siqu, izinto zokuhlanza njll. |
Isikhathi sokuthunyelwe: Ephreli-16-2021