Ua hōʻike ka hoʻokolohua i kahi alapine kiʻekiʻe o nā disinfectants ammonium quaternary e like me nā lāʻau lapaʻau no nā maʻi he nui, me nā coronaviruses: hana kēia mau mea ma ka hoʻopau ʻana i ka uhi lipid pale e hoʻopuni ana i nā maʻi e like me SARS-CoV-2 e hilinaʻi nei. Manaʻo nui ʻia nā hui ammonium quaternary e pepehi i nā maʻi a aia ma mua o 350 mau huahana ma ka Papa Inoa N a EPA: Disinfectants no ka hoʻohana ʻana e kūʻē iā SARS-CoV-2 (Mea Hoʻohui). Ua hōʻike ʻia nā ʻano disinfectant a me nā manawa hoʻopili (e pili ana me nā maʻi he nui) no nā kemika disinfecting he nui ma ka papa inoa EPA a > 140 hiki ke hoʻopau i ka maʻi i loko o kekahi mau minuke wale nō (18).
Ua alakaʻi kēia ʻike iā mākou i kahi ʻimi nui aʻe no nā hui ammonium quaternary me ka hana e kūʻē i nā coronaviruses a me ka ʻike ʻana i nā kemika i hoʻāʻo mua ʻia ma ke keʻena lapaʻau a hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau no COVID-19. ʻO kekahi o nā disinfectants i hōʻike ʻia he mea luku i nā virus (Supplementary Material) a hoʻohana nui ʻia i nā huahana mālama pilikino ʻo ia ka cetylpyridinium chloride. Loaʻa kēia hui i nā holoi waha a ua helu ʻia e ka FDA ma ke ʻano he Generally Regarded as Safe (GRAS) i mea e hoʻohana ʻia ai hoʻi he mea antimicrobial no nā huahana ʻiʻo a me nā moa (a hiki i ka 1%). Ua hoʻohana ʻia ʻo Cetylpyridinium chloride i nā hoʻokolohua lapaʻau he nui, me ke ʻano he lāʻau lapaʻau e kūʻē i nā maʻi hanu e hōʻoia ana i kona hoʻohana ʻana ma ke ʻano he antiviral. Hoʻolaha paha ʻo Cetylpyridinium i ka hoʻopau ʻana o ka virus ma ka luku ʻana i ka capsid a me kāna hana lysosomotropic, ʻo ia hoʻi, e like me ka mea i kūkākūkā ʻia ma luna, he mea maʻamau no nā hui ammonium quaternary. Hāpai kēia i ka nīnau inā paha kekahi o nā lāʻau lapaʻau i ʻike ʻia me ka hana antiviral e kūʻē iā SARS-CoV-2 in vitro e hana like, ʻo ia hoʻi hiki iā lākou ke luku i ka capsid virus a me ka hōʻiliʻili ʻana i loko o ka lysosome a i ʻole endosomes a i ka hopena e pale ana i ke komo ʻana o ka viral. Ua hōʻike ʻia nā haʻawina hou i paʻi ʻia e hiki ke hoʻēmi ʻia kēia hopena ma ka hoʻohana ʻana i nā mea hoʻopaʻa Cathepsin-L.
ʻO Cetylpyridinium chloride (CPC)
Nā hui ammonium quaternary me ka hana coronavirus i ʻike ʻia
| Molekula | Hana antiviral | ʻAno hana | Ua ʻāpono ʻia e ka FDA | Nā hoʻohana |
| ʻAmonium Chloride | ʻO ka maʻi coronavirus o ka ʻiʻo, ka maʻi hepatitis C, | Lysosomotropic | ʻAe | Nā hoʻohana like ʻole e like me ka metabolic acidosis. |
| ʻO Cetylpyridinium chloride | Ka maʻi palū, ka maʻi hepatitis B, ka poliovirus 1 | Hoʻopili i ka capsid a he lysosomotropic | ʻAe, GRAS | Antiseptic, holoi waha, lozenges cough, nā huahana mālama pilikino, nā mea hoʻomaʻemaʻe etc. |
Ka manawa hoʻouna: ʻApelila-16-2021