I whakaatuhia e te whakamātautau he nui te auau o ngā patu huakita ammonia quaternary hei rongoā mō ngā huaketo maha, tae atu ki ngā coronaviruses: ka mahi ēnei mā te whakakore i te paninga lipid tiaki e whakawhirinakihia ana e ngā huaketo pēnei i te SARS-CoV-2. E taunakihia whānuitia ana ngā matū ammonia quaternary hei patu i ngā huaketo, ā, neke atu i te 350 ngā hua kei runga i te Rārangi N a te EPA: Ngā patu huakita hei whakamahi ki te SARS-CoV-2 (Rauemi Tāpiri). Kua pūrongohia ngā kukū patu huakita me ngā wā whakapā (e pā ana ki ngā huaketo maha) mō te maha o ngā matū patu huakita kei runga i te rārangi EPA, ā, ka taea e te > 140 te whakakore i te huaketo i roto i ētahi meneti noa iho (18).
Nā ēnei mōhiohio i ārahi mātou ki tētahi rapunga whānui ake mō ngā matū ammonia quaternary he kaha ki te whawhai ki ngā mate korona me te tautuhi pea i ngā matū kua whakamatautauria i roto i te whare hauora, ā, ka taea te whakamahi hei rongoā pea mō te COVID-19. Ko tētahi o ngā patu huakita kua whakaatuhia he kino ki ngā huaketo (Rauemi Tāpiri) ā, e whakamahia whānuitia ana i roto i ngā hua tiaki whaiaro ko te cetylpyridinium chloride. Ka kitea tēnei matū i roto i ngā horoi waha, ā, kua whakarārangihia e te FDA hei Generally Regarded as Safe (GRAS) nō reira ka whakamahia hoki hei kaihoko patu huakita mō ngā hua mīti me te heihei (tae atu ki te 1%). Kua whakamahia te cetylpyridinium chloride i roto i ngā whakamātautau haumanu maha, tae atu ki te rongoā mō ngā mate manawa e whakamana ana i tōna whakamahinga hei patu huakita. Tērā pea ka whakatairanga te cetylpyridinium i te whakakorenga o te huaketo mā te whakangaro i te capsid me tana mahi lysosomotropic, e ai ki te kōrero i runga ake nei, he mea noa mō ngā matū ammonia quaternary. Ka ara ake te pātai, mēnā rānei ko ētahi o ngā rongoā kua kitea he mahi ārai huaketo ki te SARS-CoV-2 i roto i te vitro he rite tonu te mahi, arā, ka taea e rātou te whakangaro i te capsid huaketo me te kohikohi i roto i te lysosome, i ngā endosome rānei, ā, i te mutunga ka aukati i te urunga o te huaketo. Kua whakaatuhia e ētahi atu rangahau kua whakaputaina ka taea te whakaiti i tēnei pānga mā te whakamahi i ngā aukati Cathepsin-L.
Te hauota Cetylpyridinium (CPC)
Ngā pūhui ammonia quaternary me te mahi coronavirus e mōhiotia ana
| Ngā ngota | Te mahi ārai huaketo | Tikanga | Kua whakaaetia e te FDA | Ngā Whakamahinga |
| Haukiniuma Pūhaumāota | Te mate korona murine, te hepatitis C, | Lysosomotropic | Āe | Ngā momo whakamahinga tae atu ki te waikawa pūmua. |
| Cetylpyridinium chloride | Rewharewha, hepatitis B, poliovirus 1 | Ka aro ki te capsid, ā, he lysosomotropic | Āe, GRAS | He paturopi, he horoi waha, he rongoā maremare, he hua tiaki whaiaro, he kai horoi, me ētahi atu. |
Wā tuku: Paenga-whāwhā-16-2021