Cetylpyridinium chloride e le Kalafo ea COVID-19

Teko e bontšitse makhetlo a mangata a li-disinfectant tsa ammonium tsa quaternary e le kalafo ea livaerase tse ngata, ho kenyeletsoa le li-coronavirus: tsena li sebetsa ka ho tima lesira le sireletsang la lipid leo livaerase tse kang SARS-CoV-2 li itšetlehileng ka lona. Metsoako ea ammonium ea quaternary e khothaletsoa haholo ho bolaea livaerase 'me ho na le lihlahisoa tse fetang 350 ho Lethathamo la N: Li-disinfectant tsa EPA tse sebelisoang khahlanong le SARS-CoV-2 (Lisebelisoa tse Tlatsetsang. Maqhubu a li-disinfectant le linako tsa ho kopana (tse amanang le livaerase tse ngata) bakeng sa lik'hemik'hale tse ngata tsa ho bolaea livaerase lenaneng la EPA li tlalehiloe 'me tse ka holimo ho 140 li ka tima vaerase ka metsotso e seng mekae feela (18).
Tlhahisoleseling ena e re lebisitse patlong e kholoanyane ea metsoako ea ammonium ea quaternary e nang le ts'ebetso khahlanong le li-coronavirus le ho tsebahatsa lik'hemik'hale tse seng li lekoa kliniking 'me li ka sebelisoa e le kalafo e ka bang teng bakeng sa COVID-19. E 'ngoe ea li-disinfectant tse bontšitsoeng li senya livaerase (Lisebelisoa tse Tlatsetsang) le tse sebelisoang haholo lihlahisoa tsa tlhokomelo ea botho ke cetylpyridinium chloride. Motsoako ona o fumanoa haholo-holo li-mouthwash 'me o thathamisitsoe ke FDA e le Kakaretso e Recognited as Safe (GRAS) hoo e boetse e sebelisoang e le moemeli oa antimicrobial bakeng sa lihlahisoa tsa nama le likhoho (ho fihlela ho 1%). Cetylpyridinium chloride e sebelisitsoe litekong tse ngata tsa kliniki, ho kenyeletsoa le kalafo khahlanong le tšoaetso ea phefumoloho e netefatsang ts'ebeliso ea eona e le antiviral. Cetylpyridinium e ka 'na ea khothalletsa ho se sebetse ha vaerase ka ho senya capsid hammoho le ka ketso ea eona ea lysosomotropic, eo, joalo ka ha ho buisanoe kaholimo, e tloaelehileng bakeng sa metsoako ea quaternary ammonium. Sena se hlahisa potso ea hore na meriana e meng e khetholloang e na le ts'ebetso ea antiviral khahlanong le SARS-CoV-2 in vitro e itšoara ka tsela e tšoanang, e leng hore e ka 'na ea senya capsid ea kokoana-hloko hammoho le ho bokellana ka har'a lysosome kapa endosomes' me qetellong ea thibela ho kena ha kokoana-hloko. Lithuto tse ling tse hatisitsoeng li bontšitse hore phello ena e ka fokotsoa ka ho sebelisa li-inhibitor tsa Cathepsin-L.