Olu vavanyo lubonise ukuba ii-disinfectants ze-quaternary ammonium zisetyenziswa rhoqo njengonyango lweentsholongwane ezininzi, kuquka ii-coronavirus: ezi zisebenza ngokuvala i-lipid coating ekhuselayo egubungele iintsholongwane ezifana ne-SARS-CoV-2. Iikhompawundi ze-quaternary ammonium zicetyiswa kakhulu ukubulala iintsholongwane kwaye kukho iimveliso ezingaphezu kwama-350 kuLuhlu lwe-EPA: Ii-Disinfectants zokusetyenziswa ngokuchasene ne-SARS-CoV-2 (Izinto ezongezelelweyo. Uxinzelelo lwe-disinfectant kunye namaxesha okudibana (anxulunyaniswa neentsholongwane ezininzi) kwiikhemikhali ezininzi zokubulala iintsholongwane kuluhlu lwe-EPA ziye zaxelwa kwaye >140 zinokuyicima intsholongwane kwimizuzu embalwa nje (18).
Olu lwazi lusikhokelele kuphando olukhulu lweekhompawundi ze-quaternary ammonium ezisebenza ngokuchasene neentsholongwane ze-coronavirus kunye nokuchongwa kweekhemikhali esele zivavanyiwe ekliniki kwaye zingasetyenziswa njengonyango olunokwenzeka lwe-COVID-19. Enye yezibulali-ntsholongwane ezibonakaliswe njengezitshabalalisa iintsholongwane (Izinto ezongezelelweyo) kwaye zisetyenziswa kakhulu kwiimveliso zokhathalelo lomntu yi-cetylpyridinium chloride. Le khompawundi ifumaneka kakhulu kwiindawo zokuhlamba umlomo kwaye idweliswe yi-FDA njengeGenerally Regarded as Safe (GRAS) kangangokuba ikwasetyenziswa njengearhente yokulwa neentsholongwane kwimveliso yenyama kunye neenkukhu (ukuya kuthi ga kwi-1%). I-Cetylpyridinium chloride isetyenzisiwe kwizilingo ezininzi zeklinikhi, kubandakanya nonyango oluchasene nezifo zokuphefumla eziqinisekisa ukusetyenziswa kwayo njenge-antiviral. I-Cetylpyridinium inokuthi ikhuthaze ukungasebenzi kweentsholongwane ngokutshabalalisa i-capsid kunye nesenzo sayo se-lysosomotropic, njengoko kuxoxwe ngaso apha ngasentla, esiqhelekile kwiikhompawundi ze-quaternary ammonium. Oku kuphakamisa umbuzo wokuba ingaba amanye amayeza afunyenwe enomsebenzi wokulwa neentsholongwane kwi-SARS-CoV-2 kwi-vitro aziphatha ngendlela efanayo na, oko kukuthi anokutshabalalisa i-capsid yentsholongwane kunye nokuqokelelana kwi-lysosome okanye kwi-endosomes kwaye ekugqibeleni avale ukungena kwentsholongwane. Izifundo ezongezelelweyo ezipapashiweyo zibonise ukuba esi siphumo sinokuncitshiswa kukusetyenziswa kwezithinteli ze-Cathepsin-L.
I-Cetylpyridinium chloride (CPC)
Iikhompawundi ze-quaternary ammonium ezinomsebenzi owaziwayo we-coronavirus
| Imolekyuli | Umsebenzi we-antiviral | Indlela yokusebenza | Ivunyiwe yi-FDA | Ukusetyenziswa |
| I-Ammonium Chloride | I-coronavirus ye-murine, i-hepatitis C, | I-Lysosomotropic | Ewe | Iindlela ezahlukeneyo zokusetyenziswa kuquka i-metabolic acidosis. |
| I-Cetylpyridinium chloride | Umkhuhlane, i-hepatitis B, i-poliovirus 1 | Ijolise kwi-capsid kwaye yi-lysosomotropic | Ewe, i-GRAS | Ii-antiseptic, ii-mouthwash, ii-lozenges zokukhohlela, iimveliso zokhathalelo lomntu, izinto zokucoca njl.njl. |
Ixesha lokuthumela: Epreli-16-2021